Enhancement of D1 dopaminergic responses in aged LRRK2 G2019S knock-in mice

Enhancement of D1 dopaminergic responses in aged LRRK2 G2019S knock-in mice

LRRK2 G2019S is associated with familial and sporadic Parkinson's disease and G2019S knock-in mice represent a valuable model to study early changes of basal ganglia transmission associated with Parkinson's disease. Here, we performed behavioral, biochemical and neurochemical analysis in 3...

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Bibliographic Details
Main Authors: Daniela Mercatelli, Alberto Brugnoli, Anna Di Maio, Federica Albanese, Derya R. Shimshek, Alessandro Usiello, Michele Morari
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Neurobiology of Disease
Subjects:
G2019S LRRK2
LRRK2 kinase-dead
Parkinson's disease
ERK
GluA1
Microdialysis
Online Access:http://www.sciencedirect.com/science/article/pii/S096999612500097X
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http://www.sciencedirect.com/science/article/pii/S096999612500097X

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