Redox partner exchanges between spatially confined complexes control the coupling effect of cytochrome b5 on P450 CYP3A4
Abstract Cytochrome b5 (b5) plays an important role in the enhancement of the activity of specific cytochrome P450s, especially CYP3A4. Contradictory interpretations were proposed that alternatively defend conformational or redox-based mechanisms. A semi-synthetic system involving CYP3A4, its reduct...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-07-01
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| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-09060-5 |
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