Targeting the Adenosine‐Mediated Metabolic Immune Checkpoint with Engineered Probiotic for Enhanced Chemo‐Immunotherapy

Targeting the Adenosine‐Mediated Metabolic Immune Checkpoint with Engineered Probiotic for Enhanced Chemo‐Immunotherapy

Abstract Immunotherapy has revolutionized cancer treatment by leveraging the patient's immune system, yet its efficacy is often hampered by the immunosuppressive tumor microenvironment (TME). Adenosine, a key player in this milieu, suppresses immune cell activity via cAMP signaling. Here, an in...

Full description

Saved in:
Bibliographic Details
Main Authors: Jinhui Wang, Jing Wang, Zhijie Yu, Hongyu Wen, Chensi Zhao, Jiayong Zhong, Chuanle Xiao, Yingqiu Li, Jianqiao Xu, Jinquan Wang, Zong‐Wan Mao, Wei Xia
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:Advanced Science
Subjects:
adenosine deaminase
chemo‐immunotherapy
engineered probiotic
metabolic modulation
tumor microenvironment
Online Access:https://doi.org/10.1002/advs.202411813
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1002/advs.202411813

Similar Items