HBI: a hierarchical Bayesian interaction model to estimate cell-type-specific methylation quantitative trait loci incorporating priors from cell-sorted bisulfite sequencing data

HBI: a hierarchical Bayesian interaction model to estimate cell-type-specific methylation quantitative trait loci incorporating priors from cell-sorted bisulfite sequencing data

Abstract Methylation quantitative trait loci (meQTLs) quantify the effects of genetic variants on DNA methylation levels. However, most published studies utilize bulk methylation datasets composed of different cell types and limit our understanding of cell-type-specific methylation regulation. We pr...

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Main Authors: Youshu Cheng, Biao Cai, Hongyu Li, Xinyu Zhang, Gypsyamber D’Souza, Sadeep Shrestha, Andrew Edmonds, Jacquelyn Meyers, Margaret Fischl, Seble Kassaye, Kathryn Anastos, Mardge Cohen, Bradley E. Aouizerat, Ke Xu, Hongyu Zhao
Format: Article
Language:English
Published: BMC 2024-10-01
Series:Genome Biology
Subjects:
Methylation quantitative trait loci
Cell-type-specific DNA methylation
hierarchical Bayesian interaction model
Cell-sorted methylation sequencing data
Colocalization
Online Access:https://doi.org/10.1186/s13059-024-03411-7
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https://doi.org/10.1186/s13059-024-03411-7

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