Independent and temporally separated dynamics for RORγt and Foxp3 during Th17 differentiation

Independent and temporally separated dynamics for RORγt and Foxp3 during Th17 differentiation

T helper 17 and Regulatory T cells (Th17 and Treg, respectively) are two well-described lymphocyte subsets with opposing actions. The divergent fates of Th17 and Treg cells are accounted for, at least in part, by molecular antagonism that occurs between their respective specific transcription factor...

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Bibliographic Details
Main Authors: Stav Miller, Inbal Eizenberg-Magar, Shlomit Reich-Zeliger, Jacob Rimer, Irina Zaretsky, Dan Reshef, Ekaterina Kopitman, Nir Friedman, Yaron E Antebi
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Immunology
Subjects:
T-cell differentiation
time-lapse microscopy
transcription factor dynamics
micro-well array
double positive T-cells
systems immunology
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1462045/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1462045/full

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