Combined detection of inhibitors of the activin receptor signaling pathways (IASPs) by means of LC-HRMS/MS for human doping control

Combined detection of inhibitors of the activin receptor signaling pathways (IASPs) by means of LC-HRMS/MS for human doping control

Abstract Members of the transforming growth factor beta superfamily such as myostatin, activin A, and GDF-11, are dimeric cytokines signaling through activin receptors. They play important regulative roles in different biological processes as the formation of muscle and red blood cells. Therefore, i...

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Bibliographic Details
Main Authors: Panagiotis Sakellariou, Katja Walpurgis, Andreas Thomas, Alexandre Marchand, Geoff Miller, Frank Dellanna, Mario Thevis
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Scientific Reports
Subjects:
Therapeutic antibodies
Doping
Activin receptor
Fusion protein
(Immuno-)affinity purification
LC-HRMS/MS
Online Access:https://doi.org/10.1038/s41598-025-03562-y
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https://doi.org/10.1038/s41598-025-03562-y

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