γ-glutamyl transpeptidase-catalyzed polymer-enzyme-drug conjugate enhances penetration and suppression in oral squamous cell carcinoma via transdermal application

γ-glutamyl transpeptidase-catalyzed polymer-enzyme-drug conjugate enhances penetration and suppression in oral squamous cell carcinoma via transdermal application

Over the past century, the treatment of superficial malignant tumors has largely remained within systemic therapies. The major drawback of systemic administration lies in its limited killing effects specifically to superficial tumors while causing potentially severe damage to other organs. Currently...

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Bibliographic Details
Main Authors: Xinyu Zhou, Yiyi Zhang, Jianjun Xiong, Yibin Dai, Fangxing Zhu, Hongtao Sun, Dongwang Zhu, Yingying Huang, Yiran Tan, Xinxia Zhou, Tongchao Zhao, Laiping Zhong, Yichuan Pang, Zhihang Zhou
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Materials Today Bio
Subjects:
Oral squamous cell carcinoma
Antibody-enzyme conjugates
GGT
Nano-medicine
Tumor penetration
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006425005344
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