Regulation of Senescence in Cancer and Aging
Senescence is regarded as a physiological response of cells to stress, including telomere dysfunction, aberrant oncogenic activation, DNA damage, and oxidative stress. This stress response has an antagonistically pleiotropic effect to organisms: beneficial as a tumor suppressor, but detrimental by c...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
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| Series: | Journal of Aging Research |
| Online Access: | http://dx.doi.org/10.4061/2011/963172 |
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| _version_ | 1850176340789035008 |
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| author | Yahui Kong Hang Cui Charusheila Ramkumar Hong Zhang |
| author_facet | Yahui Kong Hang Cui Charusheila Ramkumar Hong Zhang |
| author_sort | Yahui Kong |
| collection | DOAJ |
| description | Senescence is regarded as a physiological response of cells to stress, including telomere dysfunction, aberrant oncogenic activation, DNA damage, and oxidative stress. This stress response has an antagonistically pleiotropic effect to organisms: beneficial as a tumor suppressor, but detrimental by contributing to aging. The emergence of senescence as an effective tumor suppression mechanism is highlighted by recent demonstration that senescence prevents proliferation of cells at risk of neoplastic transformation. Consequently, induction of senescence is recognized as a potential treatment of cancer. Substantial evidence also suggests that senescence plays an important role in aging, particularly in aging of stem cells. In this paper, we will discuss the molecular regulation of senescence its role in cancer and aging. The potential utility of senescence in cancer therapeutics will also be discussed. |
| format | Article |
| id | doaj-art-c69fdbbbcf35435094dbda82bb76fb50 |
| institution | OA Journals |
| issn | 2090-2212 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Aging Research |
| spelling | doaj-art-c69fdbbbcf35435094dbda82bb76fb502025-08-20T02:19:16ZengWileyJournal of Aging Research2090-22122011-01-01201110.4061/2011/963172963172Regulation of Senescence in Cancer and AgingYahui Kong0Hang Cui1Charusheila Ramkumar2Hong Zhang3Department of Cell Biology, University of Massachusetts Medical School, 55 Lake Avenue North, S7-125, Worcester, MA 01655, USADepartment of Cell Biology, University of Massachusetts Medical School, 55 Lake Avenue North, S7-125, Worcester, MA 01655, USADepartment of Cell Biology, University of Massachusetts Medical School, 55 Lake Avenue North, S7-125, Worcester, MA 01655, USADepartment of Cell Biology, University of Massachusetts Medical School, 55 Lake Avenue North, S7-125, Worcester, MA 01655, USASenescence is regarded as a physiological response of cells to stress, including telomere dysfunction, aberrant oncogenic activation, DNA damage, and oxidative stress. This stress response has an antagonistically pleiotropic effect to organisms: beneficial as a tumor suppressor, but detrimental by contributing to aging. The emergence of senescence as an effective tumor suppression mechanism is highlighted by recent demonstration that senescence prevents proliferation of cells at risk of neoplastic transformation. Consequently, induction of senescence is recognized as a potential treatment of cancer. Substantial evidence also suggests that senescence plays an important role in aging, particularly in aging of stem cells. In this paper, we will discuss the molecular regulation of senescence its role in cancer and aging. The potential utility of senescence in cancer therapeutics will also be discussed.http://dx.doi.org/10.4061/2011/963172 |
| spellingShingle | Yahui Kong Hang Cui Charusheila Ramkumar Hong Zhang Regulation of Senescence in Cancer and Aging Journal of Aging Research |
| title | Regulation of Senescence in Cancer and Aging |
| title_full | Regulation of Senescence in Cancer and Aging |
| title_fullStr | Regulation of Senescence in Cancer and Aging |
| title_full_unstemmed | Regulation of Senescence in Cancer and Aging |
| title_short | Regulation of Senescence in Cancer and Aging |
| title_sort | regulation of senescence in cancer and aging |
| url | http://dx.doi.org/10.4061/2011/963172 |
| work_keys_str_mv | AT yahuikong regulationofsenescenceincancerandaging AT hangcui regulationofsenescenceincancerandaging AT charusheilaramkumar regulationofsenescenceincancerandaging AT hongzhang regulationofsenescenceincancerandaging |