Metabolomic signatures in liquid biopsy are associated with overall survival in metastatic melanoma patients treated with immune checkpoint inhibitor therapy

Metabolomic signatures in liquid biopsy are associated with overall survival in metastatic melanoma patients treated with immune checkpoint inhibitor therapy

Abstract Background Immune checkpoint inhibitors (ICIs), such as anti-Cytotoxic T-Lymphocyte Antigen 4(CTLA-4) and anti-Programmed cell death protein 1 (PD-1) agents, have improved the prognosis of patients with metastatic melanoma. However, a proportion of patients develop resistance to these treat...

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Main Authors: Susan Costantini, Gabriele Madonna, Mariaelena Capone, Elena Di Gennaro, Palmina Bagnara, Federica Renza, Domenico Mallardo, Roberta Affatato, Carlo Vitagliano, Marilena Romanelli, Marilena Tuffanelli, Ester Simeone, Gennaro Ciliberto, Paolo A. Ascierto, Alfredo Budillon
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Melanoma
Metabolomics
Serum biomarkers
Immune checkpoint inhibitors
Online Access:https://doi.org/10.1186/s13046-025-03378-8
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https://doi.org/10.1186/s13046-025-03378-8

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