TRPC6-Mediated Zn<sup>2+</sup> Influx Negatively Regulates Contractile Differentiation of Vascular Smooth Muscle Cells

TRPC6-Mediated Zn<sup>2+</sup> Influx Negatively Regulates Contractile Differentiation of Vascular Smooth Muscle Cells

Vascular smooth muscle cells (VSMCs) can dynamically change their phenotype between contractile and synthetic forms in response to environmental stress, which is pivotal in maintaining vascular homeostasis and mediating pathological remodeling of blood vessels. We previously reported that suppressio...

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Bibliographic Details
Main Authors: Chenlin Su, Xinya Mi, Tomoya Ito, Yuri Kato, Akiyuki Nishimura, Ryu Nagata, Yasuo Mori, Motohiro Nishida
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Biomolecules
Subjects:
Zn<sup>2+</sup> influx
TRPC6 channel
phenotypic switching
vascular smooth muscle cells
Online Access:https://www.mdpi.com/2218-273X/15/2/267
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