Combined inhibition of ribonucleotide reductase and WEE1 induces synergistic anticancer activity in Ewing’s sarcoma cells

Combined inhibition of ribonucleotide reductase and WEE1 induces synergistic anticancer activity in Ewing’s sarcoma cells

Abstract Background Ewing’s sarcoma is a childhood bone and soft tissue cancer with poor prognosis. Treatment outcomes for Ewing’s sarcoma patients have improved only modestly over the past decades, making the development of new treatment strategies paramount. In this study, the combined targeting o...

Full description

Saved in:
Bibliographic Details
Main Authors: Judy Ziener, Julián Andrés Henao-Restrepo, Johanna Leonhardi, Max-Johann Sturm, Sabine Becker, Diana M. Morales-Prieto, Till Milde, James F. Beck, Jürgen Sonnemann
Format: Article
Language:English
Published: BMC 2025-02-01
Series:BMC Cancer
Subjects:
Ewing’s sarcoma
Targeted therapy
Ribonucleotide reductase
WEE1
PARP
Triapine
Online Access:https://doi.org/10.1186/s12885-025-13691-2
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1186/s12885-025-13691-2

Similar Items