Role of low-frequency integrase strand transfer inhibitor resistance mutations on virological outcomes in antiretroviral therapy-naïve individuals initiating second-generation integrase inhibitors

Role of low-frequency integrase strand transfer inhibitor resistance mutations on virological outcomes in antiretroviral therapy-naïve individuals initiating second-generation integrase inhibitors

Objectives: This study investigated the role of low-frequency integrase strand transfer inhibitor (INSTI) resistance mutations, detectable by next-generation sequencing (NGS), at predicting virological rebound (VR) among people with HIV (PWH) starting second-generation INSTI-based first-line regimen...

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Main Authors: Daniele Armenia, Greta Marchegiani, Daniele Spalletta, Luca Carioti, Alessandro Tavelli, Maria Concetta Bellocchi, Vincenzo Spagnuolo, Valentina Mazzotta, Eugenia Quiros-Roldan, Valeria Bono, Stefania Carrara, Sergio Lo Caputo, Antonella D’Arminio Monforte, Francesca Ceccherini-Silberstein, Stefano Rusconi, Maria Mercedes Santoro
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Journal of Global Antimicrobial Resistance
Subjects:
HIV minority resistant variants
HIV drug resistance
Next-generation sequencing
Integrase inhibitors
Dolutegravir
Bictegravir
Online Access:http://www.sciencedirect.com/science/article/pii/S221371652500075X
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