Salvage treatment of steroid-refractory acute GVHD with the off-the-shelf product of human umbilical cord mesenchymal stromal cells: a multicenter, open label, phase Ib/IIa trial

Salvage treatment of steroid-refractory acute GVHD with the off-the-shelf product of human umbilical cord mesenchymal stromal cells: a multicenter, open label, phase Ib/IIa trial

Abstract Background Acute graft-versus-host disease (aGVHD) is a life-threatening complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT), particularly if treatment is refractory. Mesenchymal stromal cells (MSCs) have demonstrated promising therapeutic effects in aGVHD, due...

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Main Authors: Yanmin Zhao, Yi Luo, Jimin Shi, Jian Yu, Lizhen Liu, Xiaoyu Lai, Huarui Fu, Yeqian Zhao, Yi Yu, Yishan Ye, Congxiao Zhang, Nainong Li, Erlie Jiang, Qiong Xie, Jundong Gu, Zhibo Han, Zhongchao Han, He Huang
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Stem Cell Research & Therapy
Subjects:
Acute graft-versus-host disease
Allogeneic hematopoietic stem cell transplantation
Mesenchymal stromal cells
Online Access:https://doi.org/10.1186/s13287-025-04446-8
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https://doi.org/10.1186/s13287-025-04446-8

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