Repurposing BCL2 inhibitors: Venetoclax protects against acinar cell necrosis in acute pancreatitis by promoting apoptosis

Repurposing BCL2 inhibitors: Venetoclax protects against acinar cell necrosis in acute pancreatitis by promoting apoptosis

Abstract Acute pancreatitis (AP), a severe inflammatory disorder of the pancreas, lacks effective pharmacological treatment. The disease is primarily driven by necrosis of pancreatic acinar cells (PACs), which intensifies inflammation and organ injury. This study explores the potential of BCL2 inhib...

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Main Authors: Jacek J. Litewka, Mateusz D. Szopa, Katarzyna Fryt, Monika A. Jakubowska, Urszula Jankowska, Bozena Skupien-Rabian, Karolina Hajduk, Ewa Werner, Kinga B. Stopa, Agnieszka A. Kusiak, Daria Krzysztofik, Zbigniew Madeja, Pawel E. Ferdek
Format: Article
Language:English
Published: Nature Publishing Group 2025-07-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07881-w
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https://doi.org/10.1038/s41419-025-07881-w

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