Cyclodextrin-Nanosponge-Loaded Cyclo-Oxygenase-2 Inhibitor-Based Topical Gel for Treatment of Psoriatic Arthritis: Formulation Design, Development, and <i>In vitro</i> Evaluations

Cyclodextrin-Nanosponge-Loaded Cyclo-Oxygenase-2 Inhibitor-Based Topical Gel for Treatment of Psoriatic Arthritis: Formulation Design, Development, and <i>In vitro</i> Evaluations

<b>Background:</b> Psoriatic arthritis (PsA), a chronic inflammatory disease, mainly affects the joints, with approximately 30% of psoriasis patients eventually developing PsA. Characterized by both innate and adaptive immune responses, PsA poses significant challenges for effective trea...

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Main Authors: Umme Hani, Sharanya Paramshetti, Mohit Angolkar, Wajan Khalid Alqathanin, Reema Saeed Alghaseb, Saja Mohammed Al Asmari, Alhanouf A. Alsaab, Farhat Fatima, Riyaz Ali M. Osmani, Ravi Gundawar
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Pharmaceuticals
Subjects:
cyclodextrin
nanosponge
solubility
controlled release
solubility enhancement
psoriatic arthritis
Online Access:https://www.mdpi.com/1424-8247/17/12/1598
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