Single-cell RNA sequencing defines distinct disease subtypes and reveals hypo-responsiveness to interferon in asymptomatic Waldenstrom’s Macroglobulinemia

Single-cell RNA sequencing defines distinct disease subtypes and reveals hypo-responsiveness to interferon in asymptomatic Waldenstrom’s Macroglobulinemia

Abstract Waldenstrom’s Macroglobulinemia (WM) is an IgM-secreting bone marrow (BM) lymphoma that is preceded by an asymptomatic state (AWM). To dissect tumor-intrinsic and immune mechanisms of progression, we perform single-cell RNA-sequencing on 294,206 BM tumor and immune cells from 30 patients wi...

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Main Authors: Romanos Sklavenitis-Pistofidis, Yoshinobu Konishi, Daniel Heilpern-Mallory, Ting Wu, Nicholas Tsakmaklis, Michelle P. Aranha, Zachary R. Hunter, Alaa K. Ali, Junko Tsuji, Nicholas J. Haradhvala, Elizabeth D. Lightbody, Katherine Towle, Laura Hevenor, Rizwan Romee, Edward L. Briercheck, Eric L. Smith, Christine-Ivy Liacos, Efstathios Kastritis, Meletios A. Dimopoulos, Steven P. Treon, Gad Getz, Irene M. Ghobrial
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-56323-w
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https://doi.org/10.1038/s41467-025-56323-w

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