Intranasal administration of a panreactive influenza antibody reveals Fc-independent mode of protection

Intranasal administration of a panreactive influenza antibody reveals Fc-independent mode of protection

Abstract Monoclonal antibodies have two core mechanisms of protection: an antibody’s antigen-binding fragment (Fab) can bind and neutralize viral pathogens and its fragment crystallizable domain (Fc) catalyzes effector functions. We investigated the relative contribution of Fab- versus Fc-mediated m...

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Main Authors: Anna L. Beukenhorst, Keira L. Rice, Jacopo Frallicciardi, Martin H. Koldijk, Carolyn M. Boudreau, Justin Crawford, Lisette A. H. M. Cornelissen, Kelly A. S. da Costa, Babette A. de Jong, Stephanie Fischinger, Boris Julg, Jaco M. Klap, Clarissa M. Koch, Zoltán Magyarics, Faez A. Nait Mohamed, Vintus Okonkwo, Lindsey Adams, Caitlin M. McCarthy, Larance Ronsard, Nigel Temperton, Helene Vietsch, Kanin Wichapong, Bertjan Ziere, Daniel Lingwood, Jaap Goudsmit
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-94314-5
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https://doi.org/10.1038/s41598-025-94314-5

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