PJ34 prevents cisplatin-induced hair cell loss via inhibition of PARP-1–AIF parthanatos

PJ34 prevents cisplatin-induced hair cell loss via inhibition of PARP-1–AIF parthanatos

The poly (ADP-ribose) polymerase-1 (PARP-1) inhibitor PJ34 acts as an anti-inflammatory and neuroprotective agent by modulating parthanatos. This study aimed to explore the protective effects of PJ34 against cisplatin-induced injury in auditory cells and to elucidate its underlying mechanism of acti...

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Bibliographic Details
Main Authors: Huiming Nong, Xiru Zhang, Yingxue Yuan, Junhong Zhang, Jingyi Zhao, Zhixin Cao
Format: Article
Language:English
Published: Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina 2025-06-01
Series:Biomolecules & Biomedicine
Subjects:
Hair cells
Hearing loss
Cisplatin
PARP inhibitor
AIF
Parthanatos
Online Access:https://www.bjbms.org/ojs/index.php/bjbms/article/view/12533
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