Inhibitory gamma-aminobutyric acidergic neurons in the anterior cingulate cortex participate in the comorbidity of pain and emotion

Inhibitory gamma-aminobutyric acidergic neurons in the anterior cingulate cortex participate in the comorbidity of pain and emotion

Pain is often comorbid with emotional disorders such as anxiety and depression. Hyperexcitability of the anterior cingulate cortex has been implicated in pain and pain-related negative emotions that arise from impairments in inhibitory gamma-aminobutyric acid neurotransmission. This review primarily...

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Bibliographic Details
Main Authors: Lu Guan, Mengting Qiu, Na Li, Zhengxiang Zhou, Ru Ye, Liyan Zhong, Yashuang Xu, Junhui Ren, Yi Liang, Xiaomei Shao, Jianqiao Fang, Junfan Fang, Junying Du
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2025-10-01
Series:Neural Regeneration Research
Subjects:
anterior cingulate cortex
anxiety
chronic pain
circuit
communication
comorbidity
depression
gamma-aminobutyric acidergic neurons
parvalbumin neurons
synaptic transmission
Online Access:https://journals.lww.com/10.4103/NRR.NRR-D-24-00429
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https://journals.lww.com/10.4103/NRR.NRR-D-24-00429

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