Separation-of-function mutants reveal the NF-κB-independent involvement of IκBα in the regulation of intestinal stemness

Separation-of-function mutants reveal the NF-κB-independent involvement of IκBα in the regulation of intestinal stemness

Summary: We have previously shown that the nuclear factor κB (NF-κB) inhibitor IκBα binds chromatin together with polycomb repressor complex 2 (PRC2) to confer responsiveness to PRC2 targets in the presence of inflammatory cues. This alternative function has been elusive in both physiological and di...

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Main Authors: Daniel Álvarez-Villanueva, Martin Floor, Laura Solé, Luis G. Palma, María Maqueda, Joan Bertran, Teresa Lobo-Jarne, Rajani Rajbhandari, Aran Merati, Laura Marruecos, Jordi Villà-Freixa, Mar Iglesias, Markus Bredel, Anna Bigas, Lluís Espinosa
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Cell Reports
Subjects:
CP: Stem cell research
Online Access:http://www.sciencedirect.com/science/article/pii/S221112472500720X
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