Limited Effects of an eIF2αS51A Allele on Neurological Impairments in the 5xFAD Mouse Model of Alzheimer’s Disease

Limited Effects of an eIF2αS51A Allele on Neurological Impairments in the 5xFAD Mouse Model of Alzheimer’s Disease

Alzheimer’s disease (AD) has been associated with increased phosphorylation of the translation initiation factor 2α (eIF2α) at serine 51. Increased phosphorylation of eIF2α alters translational control and may thereby have adverse effects on synaptic plasticity, learning, and memory. To analyze if i...

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Main Authors: Katharina Paesler, Kan Xie, Moritz M. Hettich, Magdalena E. Siwek, Devon P. Ryan, Susanne Schröder, Anna Papazoglou, Karl Broich, Ralf Müller, Astrid Trog, Alexander Garthe, Gerd Kempermann, Marco Weiergräber, Dan Ehninger
Format: Article
Language:English
Published: Wiley 2015-01-01
Series:Neural Plasticity
Online Access:http://dx.doi.org/10.1155/2015/825157
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http://dx.doi.org/10.1155/2015/825157

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