Exosomal miR-202-5p derived from iPSC-MSCs protects against myocardial infarction through inhibition of cardiomyocyte pyroptosis

Exosomal miR-202-5p derived from iPSC-MSCs protects against myocardial infarction through inhibition of cardiomyocyte pyroptosis

Abstract Background NOD-like receptor thermal protein domain associated protein 3 (NLRP3)-mediated pyroptosis of cardiomyocytes is a key contributor to the progression of myocardial infarction (MI). This study aimed to investigate whether exosomes derived from human induced pluripotent stem cell-der...

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Main Authors: Jiaqi Chen, Xiaoting Liang, Qian Han, Haiwei He, Xinran Huang, Ying Shen, Jie Qiu, Fang Lin, Cong Mai, Ziqi Li, Kexin Ma, Bei Hu, Xin Li, Yuelin Zhang
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Stem Cell Research & Therapy
Subjects:
Exosomes
Induced pluripotent stem cell
Mesenchymal stem cells
Myocardial infarction
Cardiomyocytes
Pyroptosis
Online Access:https://doi.org/10.1186/s13287-025-04390-7
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https://doi.org/10.1186/s13287-025-04390-7

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