A humanized Gs-coupled DREADD for circuit and behavior modulation

A humanized Gs-coupled DREADD for circuit and behavior modulation

Designer receptors exclusively activated by designer drugs (DREADDs) play important roles in neuroscience research and show great promise for future clinical interventions in neurological diseases. The Gs-coupled DREADD, rM3Ds, modulates excitability in neuron subsets that are sensitive to downstrea...

Full description

Saved in:

Bibliographic Details
Main Authors:	Qi Zhang, Ruiqi Wang, Liang Zhang, Mengqi Li, Jianbang Lin, Xiaoyang Lu, Yixuan Tian, Yunping Lin, Taian Liu, Yefei Chen, Yuantao Li, Jun Cao, Qiang Wu, Jinhui Wang, Zhonghua Lu, Zexuan Hong
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-04-01
Series:	Frontiers in Cellular Neuroscience
Subjects:	DREADD neuronal activation modulation transgene modification Gs-signaling D1-MSNs
Online Access:	https://www.frontiersin.org/articles/10.3389/fncel.2025.1577117/full
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Gi‐DREADD activation decreases Epithelial Na+ channel activity in renal principal cells
by: Tarek Mohamed Abd El‐Aziz, et al.
Published: (2025-06-01)

Chemogenetic silencing of the subiculum blocks acute chronic temporal lobe epilepsy
by: Jianbang Lin, et al.
Published: (2024-11-01)

Medium Spiny Neurons Mediate Timing Perception in Coordination with Prefrontal Neurons in Primates
by: Xinhe Liu, et al.
Published: (2025-04-01)

Jubilee G.S. Yunusov – 75 years!
by: article Editorial
Published: (2019-02-01)

Pharmacokinetics and Metabolism of Broad-Spectrum Antivirals Remdesivir and Obeldesivir with a Consideration to Metabolite GS-441524: Same, Similar, or Different?
by: Darius Babusis, et al.
Published: (2025-06-01)

Holistic regulation of the diabetic osteo-microenvironment via NIR-II nanocarriers with dual NO/pH responsiveness for enhanced bone regeneration
by: Xudong Xie, et al.
Published: (2025-11-01)

Generalized Space-Time Autoregressive (GS-TAR)
by: Sulis Setiya Ningsih
Published: (2019-12-01)

Quimiogenómica y Quimiogenética: Definiciones, técnicas y aplicaciones en el ámbito farmacéutico
Published: (2020-02-01)

Off-targets effects of CNO on somatosensory and anxiety-related behaviors in rats
by: Xuan Li, et al.
Published: (2025-09-01)

Genome-Wide Analysis of Soybean <i>GS3</i>-Family Genes and Functional Characterization of <i>GmGS3-1</i> Responses to Saline and Drought Stresses
by: Ting Jin, et al.
Published: (2025-02-01)

Chemogenetic inhibition of corticotropin releasing hormone neurons in the paraventricular nucleus attenuates traumatic stress-induced deficit of NREM sleep, but not REM sleep in mice
by: Andrey Kostin, et al.
Published: (2025-12-01)

HDAC6 and USP9X Control Glutamine Metabolism by Stabilizing GS to Promote Glioblastoma Tumorigenesis
by: Go Woon Kim, et al.
Published: (2025-07-01)

Effects of Eleclazine (GS6615) on the proarrhythmic electrophysiological changes induced by myocardial stretch
by: Francisco J. Chorro, et al.
Published: (2025-01-01)

Porcine Epidemic Diarrhea Virus Is Inhibited by GS-441524 During an In Vitro Infection
by: Shijuan Dong, et al.
Published: (2025-05-01)

Rapid Clinical Resolution and Differential Diagnosis of a Neurological Case of Feline Infectious Peritonitis (FIP) Using GS-441524
by: Amy Huynh, et al.
Published: (2025-04-01)

Efficacy of GS-441524 for Feline Infectious Peritonitis: A Systematic Review (2018–2024)
by: Emma Gokalsing, et al.
Published: (2025-07-01)

Validation of the Maslach burnout inventory-general survey 9-item short version (MBI-GS9) among care aides in Canadian nursing homes
by: Anni Wang, et al.
Published: (2025-01-01)

Optimization of Synthetic Glucose Oxidase Gene Using A Recombinant Combination Strategy in Pichia Pastoris GS115
by: Melika Fasihi, et al.
Published: (2022-03-01)

Chemogenetic modulation in stroke recovery: A promising stroke therapy approach
by: Xinyuan Yu, et al.
Published: (2025-07-01)

Corrigendum: The effects of chemogenetic targeting of serotonin-projecting pathways on L-DOPA-induced dyskinesia and psychosis in a bilateral rat model of Parkinson's disease
by: Natalie Lipari, et al.
Published: (2025-04-01)

The effects of chemogenetic targeting of serotonin-projecting pathways on L-DOPA-induced dyskinesia and psychosis in a bilateral rat model of Parkinson’s disease
by: Natalie Lipari, et al.
Published: (2024-11-01)

Sex-specific maladaptive responses to acute stress upon in utero THC exposure are mediated by dopamine
by: Serra Valeria, et al.
Published: (2024-12-01)

Evaluation Modeling of Electric Bus Interior Sound Quality Based on Two Improved XGBoost Algorithms Using GS and PSO
by: Enlai ZHANG, et al.
Published: (2024-04-01)

NEW CONTINUOUS AND OPEN FUNCTIONS IN TOPOLOGICAL SPACE
by: Md.Hanif Page
Published: (2015-03-01)

On Grill Sp-Open Set in Grill Topological Spaces
by: Dhanabal Saravanakumar, et al.
Published: (2018-06-01)

Research on the Interference Effects of 5G’s Key Parameters on Radio Altimeters
by: Jie Bai, et al.
Published: (2024-12-01)

Chemogenetic stimulation of phrenic motor output and diaphragm activity
by: Ethan S Benevides, et al.
Published: (2025-06-01)

Leptin signaling in POMC neurons regulates plasma leptin levels and is critical to mediate hypothalamic-pituitary-adrenal axis activation during fasting
by: Nathalia Lopes Ferreira, et al.
Published: (2025-07-01)

Prospective Analysis of Clinicopathologic Correlates of At-Home Feline Infectious Peritonitis Treatment Using GS-441524
by: Kelly Larson, et al.
Published: (2025-05-01)

Genome-wide association analysis study and genomic prediction for resistance to soybean mosaic virus in soybean population
by: Tiantian Zhao, et al.
Published: (2025-07-01)

GsMTx4-blocked PIEZO1 channel promotes myogenic differentiation and alleviates myofiber damage in Duchenne muscular dystrophy
by: Wengang Wang, et al.
Published: (2025-05-01)

Chromium-induced alkaloid production in Catharanthus roseus (L.) G.Don in vitro cultured shoots and related gene expression patterns particularly for the novel gene GS
by: Elham KHATAEE, et al.
Published: (2019-04-01)

Drug delivery systems based on mesoporous silica nanoparticles for the management of hepatic diseases
by: Boyan Liu, et al.
Published: (2025-02-01)

Dual Biocide Behaviour of Quaternary Ammonium Functionalized Mesoporous Silica Nanoparticles Loaded with Thymus Essential Oil for Stone Conservation
by: Federico Olivieri, et al.
Published: (2025-06-01)

Genome-Wide Identification of the <i>GS3</i> Gene Family and the Influence of Natural Variations in <i>BnGS3-3</i> on Salt and Cold Stress Tolerance in <i>Brassica napus</i>
by: Ting Jin, et al.
Published: (2025-04-01)

FCMI-YOLO: An efficient deep learning-based algorithm for real-time fire detection on edge devices
by: Junjie Lu, et al.
Published: (2025-01-01)

FCMI-YOLO: An efficient deep learning-based algorithm for real-time fire detection on edge devices.
by: Junjie Lu, et al.
Published: (2025-01-01)

GsMTx-4 venom toxin antagonizes biophysical modulation of metastatic traits in human osteosarcoma cells
by: Arianna Buglione, et al.
Published: (2025-03-01)

Nestin, CD44, Ki-67, GS and AQP4 expression in the brain neurogenic niches of deceased patients with liver cirrhosis of different degree
by: T. V. Shulyatnikova, et al.
Published: (2023-08-01)

Application of pulse current for dissolution of heat-resistant GS32-VI alloy
by: O. V. Chernyshova, et al.
Published: (2021-11-01)