A humanized Gs-coupled DREADD for circuit and behavior modulation

A humanized Gs-coupled DREADD for circuit and behavior modulation

Designer receptors exclusively activated by designer drugs (DREADDs) play important roles in neuroscience research and show great promise for future clinical interventions in neurological diseases. The Gs-coupled DREADD, rM3Ds, modulates excitability in neuron subsets that are sensitive to downstrea...

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Main Authors: Qi Zhang, Ruiqi Wang, Liang Zhang, Mengqi Li, Jianbang Lin, Xiaoyang Lu, Yixuan Tian, Yunping Lin, Taian Liu, Yefei Chen, Yuantao Li, Jun Cao, Qiang Wu, Jinhui Wang, Zhonghua Lu, Zexuan Hong
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Cellular Neuroscience
Subjects:
DREADD
neuronal activation
modulation
transgene modification
Gs-signaling
D1-MSNs
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2025.1577117/full
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https://www.frontiersin.org/articles/10.3389/fncel.2025.1577117/full

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