Mining, validating, and quantifying circular RNA transcriptome from total RNA as a biomarker or target

Mining, validating, and quantifying circular RNA transcriptome from total RNA as a biomarker or target

Abstract Circular RNAs (circRNAs) participate in complex diseases and have emerged as a novel biomarker and therapeutic target. It is challenging to identify circRNAs from total RNA-seq data and to validate and quantify their levels by qRT-PCR. We sought to characterize the circRNA transcriptome fro...

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Bibliographic Details
Main Authors: Tan Ze Wang, Raj Kumar Thapa, Frank Yu, Ayesha Warsi, Kassie Rong, Pious Jose, Tahereh Kashkoulinejad-Kouhi, Phyo Wei Win, Christina A. Castellani, Tina Mele, Xiufen Zheng
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Sepsis
PBMCs
Circular RNA
Circular RNA ASPH
miRNA
RBPs
Online Access:https://doi.org/10.1038/s41598-025-05652-3
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https://doi.org/10.1038/s41598-025-05652-3

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