AS-IV Attenuates Oxidative Stress-Induced Apoptosis in Zebrafish via Modulation of the AKT/NRF2/HO-1/Caspase-3 Signaling Axis

AS-IV Attenuates Oxidative Stress-Induced Apoptosis in Zebrafish via Modulation of the AKT/NRF2/HO-1/Caspase-3 Signaling Axis

As the primary active component of <i>Astragalus membranaceus</i>, Astragaloside IV (AS-IV) is widely recognized in pharmacological research for its multifaceted therapeutic potential, particularly its antioxidative, immunostimulatory, and cardioprotective properties. Oxidative stress is...

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Bibliographic Details
Main Authors: Jili Dai, Zhizhou E, Yannan Bi, Zetao Yin, Yanfang Wang, Xingyu Wang, Xiaoe Jia, Bo Zou
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Molecules
Subjects:
AS-IV
NRF2
oxidative stress
network pharmacology
zebrafish
Online Access:https://www.mdpi.com/1420-3049/30/11/2355
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