Development of human targeted extracellular vesicles loaded with shRNA minicircles to prevent parkinsonian pathology

Development of human targeted extracellular vesicles loaded with shRNA minicircles to prevent parkinsonian pathology

Abstract Background Neurological disorders are the second leading cause of death and the leading cause of disability in the world. Thus, the development of novel disease-modifying strategies is clearly warranted. We have previously developed a therapeutic approach using mouse targeted rabies virus g...

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Main Authors: Maria Izco, Carlos Sola, Martin Schleef, Marco Schmeer, María de Toro, Guglielmo Verona, Estefania Carlos, Alejandro Reinares-Sebastian, Sandra Colina, Maria Eugenia Marzo-Sola, Josune Garcia-Sanmartin, Joaquín Fernández-Irigoyen, Enrique Santamaría, Rodolfo Mugica-Vidal, Javier Blesa, Lydia Alvarez-Erviti
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Translational Neurodegeneration
Subjects:
Parkinson’s disease
Gene therapy
α-Synuclein
Human targeted extracellular vesicles
ShRNA minicircles
Online Access:https://doi.org/10.1186/s40035-025-00484-7
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https://doi.org/10.1186/s40035-025-00484-7

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