Optimizing mesenchymal stem cell therapy: from isolation to GMP-compliant expansion for clinical application

Abstract Background Mesenchymal stem cells (MSCs) are promising for cell-based therapies targeting a wide range of diseases. However, challenges in translating MSC-based therapies to clinical applications necessitate standardized protocols following Good Manufacturing Practices (GMP) guidelines. Thi...

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Bibliographic Details
Main Authors:	Michael E. Williams, Federica Banche Niclot, Sara Rota, Jaesang Lim, Janaina Machado, Ricardo de Azevedo, Katia Castillo, Samuel Adebiyi, Ranga Sreenivasan, Daniel Kota, Patrick C. Mcculloch, Francesca Taraballi
Format:	Article
Language:	English
Published:	BMC 2025-05-01
Series:	BMC Molecular and Cell Biology
Subjects:	Mesenchymal stem cells Infrapatellar fat pad-derived MSCs Stem cell therapy Good manufacturing practices Translational research
Online Access:	https://doi.org/10.1186/s12860-025-00539-7
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Optimizing mesenchymal stem cell therapy: from isolation to GMP-compliant expansion for clinical application

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