Attenuated PDGF signaling drives alveolar and microvascular defects in neonatal chronic lung disease

Attenuated PDGF signaling drives alveolar and microvascular defects in neonatal chronic lung disease

Abstract Neonatal chronic lung disease (nCLD) affects a significant number of neonates receiving mechanical ventilation with oxygen‐rich gas (MV‐O2). Regardless, the primary molecular driver of the disease remains elusive. We discover significant enrichment for SNPs in the PDGF‐Rα gene in preterms w...

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Main Authors: Prajakta Oak, Tina Pritzke, Isabella Thiel, Markus Koschlig, Daphne S Mous, Anita Windhorst, Noopur Jain, Oliver Eickelberg, Kai Foerster, Andreas Schulze, Wolfgang Goepel, Tobias Reicherzer, Harald Ehrhardt, Robbert J Rottier, Peter Ahnert, Ludwig Gortner, Tushar J Desai, Anne Hilgendorff
Format: Article
Language:English
Published: Springer Nature 2017-09-01
Series:EMBO Molecular Medicine
Subjects:
bronchopulmonary dysplasia
neonatal chronic lung disease
PDGF‐Rα
transforming growth factor‐β
VEGF‐A
Online Access:https://doi.org/10.15252/emmm.201607308
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https://doi.org/10.15252/emmm.201607308

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