Neutropenic Enterocolitis in a Pediatric Heart Transplant Recipient on Multiple Immunosuppressants
Neutropenic enterocolitis (NE) historically primarily affects pediatric patients with leukemia who are undergoing chemotherapy or who have recently received bone marrow transplants. Although a few case reports have shown NE occurring outside of this typical population, to our knowledge, this is the...
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| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Transplantation |
| Online Access: | http://dx.doi.org/10.1155/2018/3264921 |
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| author | Emily E. Miller Leigh Christopher Reardon |
| author_facet | Emily E. Miller Leigh Christopher Reardon |
| author_sort | Emily E. Miller |
| collection | DOAJ |
| description | Neutropenic enterocolitis (NE) historically primarily affects pediatric patients with leukemia who are undergoing chemotherapy or who have recently received bone marrow transplants. Although a few case reports have shown NE occurring outside of this typical population, to our knowledge, this is the first published case of NE occurring in the setting of pediatric heart transplant. This patient was diagnosed several months after pediatric heart transplant, with radiographs showing evidence of pneumatosis intestinalis. Although NE does not typically affect solid organ transplant patients, this patient had a variety of risk factors that may have predisposed her to development of NE such as severe neutropenia, supratherapeutic tacrolimus level, immunosuppression with cytotoxic agents, and elevated Epstein-Barr viral load. Fortunately, this patient improved with bowel rest, fluids, antibiotics, and alteration of her immunosuppressive regimen. However, NE can be fatal, and thus it is an important condition to consider, even in patients without leukemia or on chemotherapeutic regimens. |
| format | Article |
| id | doaj-art-c5545401945c448fb14d45a239ac6dc5 |
| institution | Kabale University |
| issn | 2090-6943 2090-6951 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Transplantation |
| spelling | doaj-art-c5545401945c448fb14d45a239ac6dc52025-02-03T05:52:12ZengWileyCase Reports in Transplantation2090-69432090-69512018-01-01201810.1155/2018/32649213264921Neutropenic Enterocolitis in a Pediatric Heart Transplant Recipient on Multiple ImmunosuppressantsEmily E. Miller0Leigh Christopher Reardon1UCLA Mattel Children’s Hospital, Pediatric Heart Transplant Program, 200 UCLA Medical Plaza Suite 330, Los Angeles, CA 90024, USAUCLA Mattel Children’s Hospital, Pediatric Heart Transplant Program, 200 UCLA Medical Plaza Suite 330, Los Angeles, CA 90024, USANeutropenic enterocolitis (NE) historically primarily affects pediatric patients with leukemia who are undergoing chemotherapy or who have recently received bone marrow transplants. Although a few case reports have shown NE occurring outside of this typical population, to our knowledge, this is the first published case of NE occurring in the setting of pediatric heart transplant. This patient was diagnosed several months after pediatric heart transplant, with radiographs showing evidence of pneumatosis intestinalis. Although NE does not typically affect solid organ transplant patients, this patient had a variety of risk factors that may have predisposed her to development of NE such as severe neutropenia, supratherapeutic tacrolimus level, immunosuppression with cytotoxic agents, and elevated Epstein-Barr viral load. Fortunately, this patient improved with bowel rest, fluids, antibiotics, and alteration of her immunosuppressive regimen. However, NE can be fatal, and thus it is an important condition to consider, even in patients without leukemia or on chemotherapeutic regimens.http://dx.doi.org/10.1155/2018/3264921 |
| spellingShingle | Emily E. Miller Leigh Christopher Reardon Neutropenic Enterocolitis in a Pediatric Heart Transplant Recipient on Multiple Immunosuppressants Case Reports in Transplantation |
| title | Neutropenic Enterocolitis in a Pediatric Heart Transplant Recipient on Multiple Immunosuppressants |
| title_full | Neutropenic Enterocolitis in a Pediatric Heart Transplant Recipient on Multiple Immunosuppressants |
| title_fullStr | Neutropenic Enterocolitis in a Pediatric Heart Transplant Recipient on Multiple Immunosuppressants |
| title_full_unstemmed | Neutropenic Enterocolitis in a Pediatric Heart Transplant Recipient on Multiple Immunosuppressants |
| title_short | Neutropenic Enterocolitis in a Pediatric Heart Transplant Recipient on Multiple Immunosuppressants |
| title_sort | neutropenic enterocolitis in a pediatric heart transplant recipient on multiple immunosuppressants |
| url | http://dx.doi.org/10.1155/2018/3264921 |
| work_keys_str_mv | AT emilyemiller neutropenicenterocolitisinapediatrichearttransplantrecipientonmultipleimmunosuppressants AT leighchristopherreardon neutropenicenterocolitisinapediatrichearttransplantrecipientonmultipleimmunosuppressants |