CD47 is required for mesenchymal progenitor proliferation and fracture repair

Abstract CD47 is a ubiquitous and pleiotropic cell-surface receptor. Disrupting CD47 enhances injury repair in various tissues but the role of CD47 has not been studied in bone injuries. In a murine closed-fracture model, CD47-null mice showed decreased callus bone formation as assessed by microcomp...

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Bibliographic Details
Main Authors: Robert L. Zondervan, Christina A. Capobianco, Daniel C. Jenkins, John D. Reicha, Livia Fredrick, Charles Lam, Jeanna T. Schmanski, Jeffery S. Isenberg, Jaimo Ahn, Ralph S. Marcucio, Kurt D. Hankenson
Format: Article
Language:English
Published: Nature Publishing Group 2025-03-01
Series:Bone Research
Online Access:https://doi.org/10.1038/s41413-025-00409-0
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