Basal ganglia deep brain stimulation restores cognitive flexibility and exploration-exploitation balance disrupted by NMDA-R antagonism

Basal ganglia deep brain stimulation restores cognitive flexibility and exploration-exploitation balance disrupted by NMDA-R antagonism

Abstract Learning thrives on cognitive flexibility and exploration. Subjects with schizophrenia have impaired cognitive flexibility and maladaptive exploration patterns. The basal ganglia-dorsolateral prefrontal cortex (BG-DLPFC) network plays a significant role in learning processes. However, how t...

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Main Authors: Nir Asch, Noa Rahamim, Anna Morozov, Uri Werner-Reiss, Zvi Israel, Rony Paz, Hagai Bergman
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60044-5
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https://doi.org/10.1038/s41467-025-60044-5

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