Metabolic Syndrome Nonalcoholic Steatohepatitis Male Mouse With Adeno‐Associated Viral Renin as a Novel Model for Heart Failure With Preserved Ejection Fraction

Metabolic Syndrome Nonalcoholic Steatohepatitis Male Mouse With Adeno‐Associated Viral Renin as a Novel Model for Heart Failure With Preserved Ejection Fraction

Background Heart failure with preserved ejection fraction (HFpEF) currently accounts for more than half of patients with HF, with limited approved evidence‐based therapies. HFpEF is a complex multifactorial disease associated with hypertension, obesity, diabetes, and renal dysfunction. In addition t...

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Main Authors: Yuji Shi, Patricia Perez‐Bonilla, Xian Chen, Kelly Tam, Mackenzie Marshall, Jeffrey Morin, Brianna LaViolette, Nouaying R. Kue, Federico Damilano, Russell A. Miller, Bei B. Zhang, Rachel J. Roth Flach, Dinesh Hirenallur‐Shanthappa
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
cardiometabolism
empagliflozin
HFpEF
mouse models
MSNASH
renin
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.124.035894
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https://www.ahajournals.org/doi/10.1161/JAHA.124.035894

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