Collagen VI microfibril structure reveals mechanism for molecular assembly and clustering of inherited pathogenic mutations

Abstract Collagen VI links the cell surface to the extracellular matrix to provide mechanical strength to most mammalian tissues, and is linked to human diseases including muscular dystrophy, fibrosis, cardiovascular disease and osteoarthritis. Collagen VI assembles from heterotrimers of three diffe...

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Bibliographic Details
Main Authors: Alan R. F. Godwin, Mark H. Becker, Rana Dajani, Matthew Snee, Alan M. Roseman, Clair Baldock
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62923-3
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