Distinctive chromosomal, mutational and transcriptional profiling in colon versus rectal cancers

Distinctive chromosomal, mutational and transcriptional profiling in colon versus rectal cancers

Abstract Background Colorectal cancer (CRC) encompasses tumors arising in the colon (CC) and rectum (RC), often treated as a single disease despite emerging evidence of biological divergence. Understanding the molecular differences between CC and RC is critical for improving diagnosis, prognosis, an...

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Main Authors: Maria Teresa De Angelis, Antonia Rizzuto, Angela Amaddeo, Carlo Sagnelli, Niccolò Vono, Michela Reda, Valentina Lise, Luca Parrillo, Carmela De Marco, Donatella Malanga, Gianluca Santamaria, Giuseppe Viglietto
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Journal of Translational Medicine
Subjects:
Colon cancer
Rectal cancer
Genomic profiling
Transcriptomic analysis
Copy number alterations
Driver genes
Online Access:https://doi.org/10.1186/s12967-025-06908-2
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https://doi.org/10.1186/s12967-025-06908-2

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