A bone adhesive enhances osteoporotic fracture repair by regulating bone homeostasis
Abstract Patients suffering from osteoporotic fractures often require effective fixation and subsequent bone repair. However, the currently available materials are functionally limited and often fail to improve outcomes in this patient population. In this study, we developed orthopedic adhesives dop...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-04-01
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| Series: | NPG Asia Materials |
| Online Access: | https://doi.org/10.1038/s41427-024-00539-7 |
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| author | Shenghui Su Jiajun Xie Jian Gao Shencai Liu Xieping Dong Jianwei Li Zhong Feng Gao Keyuan Chen Weilu Liu |
| author_facet | Shenghui Su Jiajun Xie Jian Gao Shencai Liu Xieping Dong Jianwei Li Zhong Feng Gao Keyuan Chen Weilu Liu |
| author_sort | Shenghui Su |
| collection | DOAJ |
| description | Abstract Patients suffering from osteoporotic fractures often require effective fixation and subsequent bone repair. However, the currently available materials are functionally limited and often fail to improve outcomes in this patient population. In this study, we developed orthopedic adhesives doped with romosozumab-loaded mesoporous bioactive glass nanoparticles to aid in osteoporotic fracture fixation and restore dysregulated bone homeostasis. These adhesives were designed to promote osteoblast formation while simultaneously inhibiting osteoclastic bone-resorbing activity, thus working synergistically to promote the healing of osteoporotic fractures. Orthopedic adhesives exhibit injectability, reversible adhesiveness, and malleability, enhancing their adaptability to complex clinical scenarios. Furthermore, the release of romosozumab from mesoporous bioactive glass nanoparticles accelerated osteogenesis and inhibited osteoclastogenesis, delaying the bone resorption process. This dual action contributes to the regulation of bone regeneration and remodeling. Notably, our orthopedic adhesive could restore the disrupted bone homeostasis associated with osteoporotic fractures. |
| format | Article |
| id | doaj-art-c4fcc271d7c4418e9c6503a7345234b0 |
| institution | Kabale University |
| issn | 1884-4057 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | NPG Asia Materials |
| spelling | doaj-art-c4fcc271d7c4418e9c6503a7345234b02025-01-19T12:29:06ZengNature PortfolioNPG Asia Materials1884-40572024-04-0116111710.1038/s41427-024-00539-7A bone adhesive enhances osteoporotic fracture repair by regulating bone homeostasisShenghui Su0Jiajun Xie1Jian Gao2Shencai Liu3Xieping Dong4Jianwei Li5Zhong Feng Gao6Keyuan Chen7Weilu Liu8Department of Orthopaedics, Ningde Municipal Hospital of Ningde Normal UniversityDivision of Orthopaedic Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical UniversityDivision of Orthopaedic Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical UniversityDivision of Orthopaedic Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical UniversityJiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical CollegeDivision of Orthopaedics and Traumatology, Department of Orthopaedics, Nanfang Hospital, Southern Medical UniversityKey Laboratory of Interfacial Reaction & Sensing Analysis in Universities of Shandong, School of Chemistry and Chemical Engineering, University of JinanDepartment of Orthopaedics, Guangzhou First People’s Hospital, South China University of TechnologyDivision of Orthopaedic Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical UniversityAbstract Patients suffering from osteoporotic fractures often require effective fixation and subsequent bone repair. However, the currently available materials are functionally limited and often fail to improve outcomes in this patient population. In this study, we developed orthopedic adhesives doped with romosozumab-loaded mesoporous bioactive glass nanoparticles to aid in osteoporotic fracture fixation and restore dysregulated bone homeostasis. These adhesives were designed to promote osteoblast formation while simultaneously inhibiting osteoclastic bone-resorbing activity, thus working synergistically to promote the healing of osteoporotic fractures. Orthopedic adhesives exhibit injectability, reversible adhesiveness, and malleability, enhancing their adaptability to complex clinical scenarios. Furthermore, the release of romosozumab from mesoporous bioactive glass nanoparticles accelerated osteogenesis and inhibited osteoclastogenesis, delaying the bone resorption process. This dual action contributes to the regulation of bone regeneration and remodeling. Notably, our orthopedic adhesive could restore the disrupted bone homeostasis associated with osteoporotic fractures.https://doi.org/10.1038/s41427-024-00539-7 |
| spellingShingle | Shenghui Su Jiajun Xie Jian Gao Shencai Liu Xieping Dong Jianwei Li Zhong Feng Gao Keyuan Chen Weilu Liu A bone adhesive enhances osteoporotic fracture repair by regulating bone homeostasis NPG Asia Materials |
| title | A bone adhesive enhances osteoporotic fracture repair by regulating bone homeostasis |
| title_full | A bone adhesive enhances osteoporotic fracture repair by regulating bone homeostasis |
| title_fullStr | A bone adhesive enhances osteoporotic fracture repair by regulating bone homeostasis |
| title_full_unstemmed | A bone adhesive enhances osteoporotic fracture repair by regulating bone homeostasis |
| title_short | A bone adhesive enhances osteoporotic fracture repair by regulating bone homeostasis |
| title_sort | bone adhesive enhances osteoporotic fracture repair by regulating bone homeostasis |
| url | https://doi.org/10.1038/s41427-024-00539-7 |
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