Systematic in vivo analysis of the intrinsic determinants of amyloid Beta pathogenicity.

Systematic in vivo analysis of the intrinsic determinants of amyloid Beta pathogenicity.

Protein aggregation into amyloid fibrils and protofibrillar aggregates is associated with a number of the most common neurodegenerative diseases. We have established, using a computational approach, that knowledge of the primary sequences of proteins is sufficient to predict their in vitro aggregati...

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Main Authors: Leila M Luheshi, Gian Gaetano Tartaglia, Ann-Christin Brorsson, Amol P Pawar, Ian E Watson, Fabrizio Chiti, Michele Vendruscolo, David A Lomas, Christopher M Dobson, Damian C Crowther
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-10-01
Series:PLoS Biology
Online Access:https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.0050290&type=printable
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https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.0050290&type=printable

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