Michael Acceptor Compounds as Hemoglobin Oxygen Affinity Modulators for Reversing Sickling of Red Blood Cells

Michael Acceptor Compounds as Hemoglobin Oxygen Affinity Modulators for Reversing Sickling of Red Blood Cells

<b>Background/Objectives</b>: Sickle cell disease (SCD) is caused by a β-globin gene mutation (βGlu6Val) that produces sickle hemoglobin (HbS). When deoxygenated, HbS polymerizes, leading to red blood cell (RBC) sickling; therefore, hemoglobin is a central therapeutic target for SCD. Cur...

Full description

Saved in:
Bibliographic Details
Main Authors: Khadijah A. Mohammad, Asala H. Naghi, Mohini S. Ghatge, Benita Balogun, Mariana Macias, Salma Roland, Albert Opare, Osheiza Abdulmalik, Martin K. Safo, Abdelsattar M. Omar, Moustafa E. El-Araby
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Pharmaceuticals
Subjects:
hemoglobin
sickle cell disease
Michael acceptor
antisickling
Hb oxygen affinity
polymerization
Online Access:https://www.mdpi.com/1424-8247/18/6/783
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://www.mdpi.com/1424-8247/18/6/783

Similar Items