A Short-Chain Fatty Acid, Butyrate, Suppresses the Hyperexcitability of Rat Nociceptive Primary Neurons Involved in Inflammatory Hyperalgesia

A Short-Chain Fatty Acid, Butyrate, Suppresses the Hyperexcitability of Rat Nociceptive Primary Neurons Involved in Inflammatory Hyperalgesia

While gut microbiota-derived short-chain fatty acids (SCFAs) are recognized to modulate pathological pain by decreasing inflammation, the neurophysiological basis for SCFAs, butyrate’s ability to reduce hyperexcitability in nociceptive primary neurons during inflammatory conditions is still unknown....

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Bibliographic Details
Main Authors: Yukito Sashide, Syogo Utugi, Mamoru Takeda
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Molecules
Subjects:
extracellular single-unit recording
gut microbiota
SCFAs
inflammation
peripheral sensitization
COX-2
Online Access:https://www.mdpi.com/1420-3049/30/11/2407
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