BRCA1 promoter hypermethylation is not associated with germline variants in Polish breast cancer patients

BRCA1 promoter hypermethylation is not associated with germline variants in Polish breast cancer patients

Abstract Background Methylation of BRCA1 has been associated with an increased risk of breast cancer and specific clinical characteristics of the disease. In the British population, the genetic alteration c.-107 A/T has been shown to cause allelic methylation, leading to familial breast and ovarian...

Full description

Saved in:
Bibliographic Details
Main Authors: Karolina Prajzendanc, Paweł Domagała, Jolanta Hybiak, Wojciech Kluźniak, Cezary Cybulski, Katarzyna Białkowska, Alicja Ogrodniczak, Janusz Ryś, Aleksandra Sejda, Marek Szwiec, Joanna Tomiczek-Szwiec, Tomasz Kluz, Roksana Dwornik, Dagmara Cylwik, Jacek Gronwald, Jan Lubiński, Anna Jakubowska
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Hereditary Cancer in Clinical Practice
Subjects:
BRCA1 gene
Methylation
Breast cancer
Online Access:https://doi.org/10.1186/s13053-025-00317-8
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1186/s13053-025-00317-8

Similar Items