Multiomics identifies tumor-intrinsic SREBP1 driving immune exclusion in hepatocellular carcinoma

Multiomics identifies tumor-intrinsic SREBP1 driving immune exclusion in hepatocellular carcinoma

Immune checkpoint inhibitors (ICI) have improved patient outcomes in hepatocellular carcinoma (HCC); however, most patients do not experience durable benefit. The non-T cell-inflamed tumor microenvironment, characterized by limited CD8+ T-cell infiltration, reduced dendritic cell function, and low i...

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Main Authors: Jie Chen, Arjun Singh, Riyue Bao, Jason John Luke, Sarah Newman, Aatur Singhi, Carsten Krieg, Ryan Augustin, Aofei Li, Brian Isett, Rebekah E Dadey, Ruxuan Li, Jake Griner, Joseph A Manning, Satdarshan P Monga, David A A Geller, Ioannis K Zervantonakis
Format: Article
Language:English
Published: BMJ Publishing Group 2025-06-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/13/6/e011537.full
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https://jitc.bmj.com/content/13/6/e011537.full

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