Direction and modality of transcription changes caused by TAD boundary disruption in Slc29a3/Unc5b locus depends on tissue-specific epigenetic context

Direction and modality of transcription changes caused by TAD boundary disruption in Slc29a3/Unc5b locus depends on tissue-specific epigenetic context

Abstract Background Topologically associating domains (TADs) are believed to play a role in the regulation of gene expression by constraining or guiding interactions between the regulatory elements. While the impact of TAD perturbations is typically studied in developmental genes with highly cell-ty...

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Main Authors: Paul Salnikov, Polina Belokopytova, Alexandra Yan, Emil Viesná, Alexey Korablev, Irina Serova, Varvara Lukyanchikova, Yana Stepanchuk, Nikita Torgunakov, Savelii Tikhomirov, Veniamin Fishman
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Epigenetics & Chromatin
Online Access:https://doi.org/10.1186/s13072-025-00618-1
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https://doi.org/10.1186/s13072-025-00618-1

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