Farnesoid X Receptor Regulated Sepsis‐Induced Abnormal Bile Acid Metabolism via the Fibroblast Growth Factor 15/Fibroblast Growth Factor Receptor 4 Pathway

Farnesoid X Receptor Regulated Sepsis‐Induced Abnormal Bile Acid Metabolism via the Fibroblast Growth Factor 15/Fibroblast Growth Factor Receptor 4 Pathway

Abstract Objective The study aims to investigate the mechanism of Farnesoid X receptor (FXR) activation in sepsis‐induced abnormal bile acid metabolism and the metabolism status of each bile acid type. Methods The sepsis mouse model was developed via lipopolysaccharide intraperitoneal injection and...

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Bibliographic Details
Main Authors: Ziyang Zhou, Dan Xu, Liou Huang, Yuhui Cui, Hui Chen, Jianguo Tang
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:Immunity, Inflammation and Disease
Subjects:
bile acid
farnesoid X receptor
FGF15/FXFR pathway
metabolomics
sepsis
Online Access:https://doi.org/10.1002/iid3.70155
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https://doi.org/10.1002/iid3.70155

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