Distinct role of claustrum and anterior cingulate cortex bidirectional circuits in methamphetamine taking and seeking

Abstract Methamphetamine (METH) addiction involves escalating intake with strong cue reactivity, and high relapse risk, yet its neural mechanism remains unclear. Using c-Fos mapping and machine learning, we identified the claustrum (CLA), a subcortical region reciprocally connected with the anterior...

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Bibliographic Details
Main Authors: Manqing Wu, Miaojun Lai, Yiyin Zhou, Yingjie Cheng, Sai Shi, Fangmin Wang, Huizhen Liu, Min Zhao, Wenhua Zhou
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62188-w
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