Saxagliptin suppresses degradation of type II collagen and aggrecan in primary human chondrocytes: a therapeutic implication in osteoarthritis

Saxagliptin suppresses degradation of type II collagen and aggrecan in primary human chondrocytes: a therapeutic implication in osteoarthritis

Osteoarthritis (OA) is a major public health concern for which a reliable non-invasive treatment option has yet to be developed. In the present study, we investigated the effects of saxagliptin, a novel dipeptidyl peptidase IV (DPP-4) inhibitor, on several important aspects of the pathophysiology of...

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Bibliographic Details
Main Authors: Ning Hu, Xuan Gong, Shijie Yin, Qi Li, Hao Chen, Yuwan Li, Feilong Li, Leilei Qing, Jianye Yang, Sizheng Zhu, Jiawei Wang, Junchao Li
Format: Article
Language:English
Published: Taylor & Francis Group 2019-12-01
Series:Artificial Cells, Nanomedicine, and Biotechnology
Subjects:
Saxagliptin
osteoarthritis (OA)
metalloproteinases (MMP)
type II collagen
ADAMTS
aggrecan
Online Access:https://www.tandfonline.com/doi/10.1080/21691401.2019.1647223
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https://www.tandfonline.com/doi/10.1080/21691401.2019.1647223

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