Cardiac function and architecture are maintained in a model of cardiorestricted overexpression of the prorenin-renin receptor.

Cardiac function and architecture are maintained in a model of cardiorestricted overexpression of the prorenin-renin receptor.

The (pro)renin-renin receptor, (P)RR has been claimed to be a novel element of the renin-angiotensin system (RAS). The function of (P)RR has been widely studied in renal and vascular pathology but the cardio-specific function of (P)RR has not been studied in detail. We therefore generated a transgen...

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Main Authors: Hasan Mahmud, Wellington Mardoqueu Candido, Linda van Genne, Inge Vreeswijk-Baudoin, Hongjuan Yu, Bart van de Sluis, Jan van Deursen, Wiek H van Gilst, Herman H W Silljé, Rudolf A de Boer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0089929&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0089929&type=printable

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