Case Report: Medullary carcinoma of the pancreas with MLH1 promoter hypermethylation, induced deficient mismatch repair, successfully treated with an immune checkpoint inhibitor

Case Report: Medullary carcinoma of the pancreas with MLH1 promoter hypermethylation, induced deficient mismatch repair, successfully treated with an immune checkpoint inhibitor

We report the case of a 75-year-old woman with a pancreatic body mass. Pathological findings from endoscopic ultrasonography-guided fine-needle aspiration revealed medullary carcinoma of the pancreas (MCP). Deficient mismatch repair (dMMR) and high microsatellite instability (MSI-H) were identified...

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Main Authors: Koushiro Ohtsubo, Shigeki Sato, Hiroyuki Sakaguchi, Hiroshi Kotani, Akihiro Nishiyama, Kaname Yamashita, Seiji Yano, Fumihito Toshima, Dai Inoue, Toshifumi Gabata, Hiroko Ikeda, Atsushi Watanabe, Kenji Notohara, Takao Fujisawa, Yoshiaki Nakamura, Takayuki Yoshino, Kunio Miyake, Kazuhiro Miwa, Shinji Takeuchi
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Oncology
Subjects:
medullary carcinoma of the pancreas
deficient mismatch repair
microsatellite instability
MLH1 hypermethylation
immune checkpoint inhibitor
pembrolizumab
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1551038/full
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https://www.frontiersin.org/articles/10.3389/fonc.2025.1551038/full

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