PYGO1 drives gastric cancer progression via the ITGB1/CD47 axis and is therapeutically targeted by pentagalloylglucose

PYGO1 drives gastric cancer progression via the ITGB1/CD47 axis and is therapeutically targeted by pentagalloylglucose

Abstract Background Gastric cancer (GC) represents a significant therapeutic challenge due to its aggressive progression and limited treatment options, emphasizing the urgent need for novel therapeutic targets and strategies. Although PYGO1 functions as a Wnt co-transcriptional activator and chromat...

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Main Authors: Yanjuan Jia, Yaling Li, Yan Li, Yonghong Li, Tao Qu, Zhuomin Fu, Yuanyuan Ma, Zhenhao Li, Wanxia Wang, Miao Yu, Xiaojie Jin, Xiaoling Gao, Yongqi Liu
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Translational Medicine
Subjects:
Gastric cancer
PYGO1
M2 macrophage infiltration
ITGB1/CD47 axis
Pentagalloylglucose
Online Access:https://doi.org/10.1186/s12967-025-06638-5
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https://doi.org/10.1186/s12967-025-06638-5

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