Polygenic Risk Score Improves Melanoma Risk Assessment in a Patient Cohort from the Veneto Region of Italy

Polygenic Risk Score Improves Melanoma Risk Assessment in a Patient Cohort from the Veneto Region of Italy

Recent genome-wide association studies (GWASs) have identified many single nucleotide polymorphisms (SNPs) that alone weakly affect melanoma risk, but their combined effect on a polygenic risk score (PRS) can have a far bigger impact on estimating risk. However, the PRS is not yet at the stage of be...

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Main Authors: Stefania Pellegrini, Thomas P. Potjer, Paola Del Bianco, Antonella Vecchiato, Alessio Fabozzi, Luisa Piccin, Debora Tonello, Nienke van der Stoep, Emily Tinsley, Maria Teresa Landi, Mark M. Iles, Chiara Menin
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Biology
Subjects:
melanoma
genetic predisposition
polygenic risk score
risk factors
multiple primary melanoma
Online Access:https://www.mdpi.com/2079-7737/13/11/954
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