A physiologically-based pharmacokinetic model for the antibiotic ertapenem
Ertapenem is an antibiotic commonly used to treat a broad spectrum of infections, which is part of a broader class of antibiotics called carbapenem. Unlike other carbapenems, ertapenem has a longer half-life and thus only has to be administered once a day. A physiologically-based pharmacokinetic (P...
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AIMS Press
2015-09-01
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| Series: | Mathematical Biosciences and Engineering |
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| Online Access: | https://www.aimspress.com/article/doi/10.3934/mbe.2016.13.119 |
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| author | Michele L. Joyner Cammey C. Manning Whitney Forbes Michelle Maiden Ariel N. Nikas |
| author_facet | Michele L. Joyner Cammey C. Manning Whitney Forbes Michelle Maiden Ariel N. Nikas |
| author_sort | Michele L. Joyner |
| collection | DOAJ |
| description | Ertapenem is an antibiotic commonly used to treat a broad spectrum of infections, which is part of a broader class of antibiotics called carbapenem. Unlike other carbapenems, ertapenem has a longer half-life and thus only has to be administered once a day. A physiologically-based pharmacokinetic (PBPK) model was developed to investigate the uptake, distribution, and elimination of ertapenem following a single one gram dose. PBPK modeling incorporates known physiological parameters such as body weight, organ volumes, and blood flow rates in particular tissues. Furthermore, ertapenem is highly bound in human blood plasma; therefore, nonlinear binding is incorporated in the model since only the free portion of the drug can saturate tissues and, hence, is the only portion of the drug considered to be medicinally effective. Parameters in the model were estimated using a least squares inverse problem formulation with published data for blood concentrations of ertapenem for normal height, normal weight males. Finally, an uncertainty analysis of the parameter estimation and model predictions is presented. |
| format | Article |
| id | doaj-art-c41e0147f8f64a30af9c7a440d3e4a37 |
| institution | Kabale University |
| issn | 1551-0018 |
| language | English |
| publishDate | 2015-09-01 |
| publisher | AIMS Press |
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| series | Mathematical Biosciences and Engineering |
| spelling | doaj-art-c41e0147f8f64a30af9c7a440d3e4a372025-01-24T02:34:05ZengAIMS PressMathematical Biosciences and Engineering1551-00182015-09-0113111913310.3934/mbe.2016.13.119A physiologically-based pharmacokinetic model for the antibiotic ertapenemMichele L. Joyner0Cammey C. Manning1Whitney Forbes2Michelle Maiden3Ariel N. Nikas4Department of Mathematics & Statistics, East Tennessee State University, Johnson City, TN, 37614Department of Mathematics and Computer Science, Meredith College, Raleigh, NC, 27607Department of Mathematics & Statistics, East Tennessee State University, Johnson City, TN, 37614Department of Mathematics & Computer Science, Meredith College, Raleigh, NC, 27607Department of Mathematics & Computer Science, Meredith College, Raleigh, NC, 27607Ertapenem is an antibiotic commonly used to treat a broad spectrum of infections, which is part of a broader class of antibiotics called carbapenem. Unlike other carbapenems, ertapenem has a longer half-life and thus only has to be administered once a day. A physiologically-based pharmacokinetic (PBPK) model was developed to investigate the uptake, distribution, and elimination of ertapenem following a single one gram dose. PBPK modeling incorporates known physiological parameters such as body weight, organ volumes, and blood flow rates in particular tissues. Furthermore, ertapenem is highly bound in human blood plasma; therefore, nonlinear binding is incorporated in the model since only the free portion of the drug can saturate tissues and, hence, is the only portion of the drug considered to be medicinally effective. Parameters in the model were estimated using a least squares inverse problem formulation with published data for blood concentrations of ertapenem for normal height, normal weight males. Finally, an uncertainty analysis of the parameter estimation and model predictions is presented.https://www.aimspress.com/article/doi/10.3934/mbe.2016.13.119ertapenemphysiologically based pharmacokinetic model (pbpk)free concentrationordinary differentialequations.bound concentration |
| spellingShingle | Michele L. Joyner Cammey C. Manning Whitney Forbes Michelle Maiden Ariel N. Nikas A physiologically-based pharmacokinetic model for the antibiotic ertapenem Mathematical Biosciences and Engineering ertapenem physiologically based pharmacokinetic model (pbpk) free concentration ordinary differentialequations. bound concentration |
| title | A physiologically-based pharmacokinetic model for the antibiotic ertapenem |
| title_full | A physiologically-based pharmacokinetic model for the antibiotic ertapenem |
| title_fullStr | A physiologically-based pharmacokinetic model for the antibiotic ertapenem |
| title_full_unstemmed | A physiologically-based pharmacokinetic model for the antibiotic ertapenem |
| title_short | A physiologically-based pharmacokinetic model for the antibiotic ertapenem |
| title_sort | physiologically based pharmacokinetic model for the antibiotic ertapenem |
| topic | ertapenem physiologically based pharmacokinetic model (pbpk) free concentration ordinary differentialequations. bound concentration |
| url | https://www.aimspress.com/article/doi/10.3934/mbe.2016.13.119 |
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